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Calculated creatinine clearances (m L/min) are only estimates.

In patients with marked renal impairment, it may be more convenient to give maintenance doses of 250 to 1000 mg once every several days rather than administering the drug on a daily basis.[IJPC - background info] Osmolarity: 2 grams of vancomycin added to 100 m L of 0.9% sodium chloride injection has a calculated osmolarity of 348 m Osm/L, however the actual osmolarity using an osmometer is much lower (~ 230) or HYPOTONIC.Further, vancomycin is very acidic - p H of ~ 3.4 (admixture). bags have demonstrated chemical stability (potency, p H of reconstituted solution and clarity of solution) for up to one week at refrigerated temperature. bags have demonstrated chemical stability (potency, p H of reconstituted solution and clarity of solution) for up to 24 hours at room temperature.The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.PLEASE READ THE DISCLAIMERMinimizing risk of thrombophlebitis: * See important points listed further down the page....

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